Sedgwick County is fairly conservative for an urban county. It has only gone Democratic in a presidential election once since 1944. Democratic strength is concentrated in Wichita, while the suburban areas are strongly Republican. However, the county often backs Democrats for governorship - most recently Laura Kelly in 2018. This makes it a bellwether in local Kansas elections, with the statewide winner almost always winning the county. The last Democratic Senate candidate to win the county was Bill Roy in 1974, while Kansas as a whole has not been represented by a Democrat in the Senate since 1938.

Sedgwick County was a prohibition, or "dry", county until the Kansas Constitution was amended in 1986 and voters approved the sale of alcoholic liquor by the individual drink with a 30 percent food sales requirement. The food sales requirement was removed with voter approval in 1988.

The county voted "No" on the 2022 Kansas Value Them Both Amendment, an anti-abortion ballot measure, by 58% to 42% despite backing Donald Trump with 54% of the vote to Joe Biden's 43% in the 2020 presidential election.